Based on questionnaire method, the present study was conducted among 2823 primary and junior school students in Shanxi and Henan provinces to explore the mechanism of the relationship between interparental conflict and depressive symptoms. The results showed that: 1) interparental conflict, parent-child relationship, self-esteem were significantly correlated with depressive symptoms;2) interparental conflict was positively predicted depressive symptoms in which the parent-child relationship played a mediating role;3) self-esteem moderated the first half and second half of the mediation process in which interparental conflict affected depression symptoms through parent-child relationship.