The present study aimed at exploring the effects of effort-reward imbalance and occupational well-being on turnover intention among rural teachers. A total of 358 rural teachers in Sichuan Province completed a set of questionnaires including Effort-Reward Imbalance Scale, Occupational Well-Being Scale and Turnover Intention Questionnaire. The results showed that: 1) rural teachers’ effort-reward ratio significantly improved turnover intention after controlling for monthly income, age and teaching age; 2) rural teachers’ occupational well-being partially mediated the effect of effort-reward ratio on turnover intention; 3) rural teachers’ overcommitment moderated the effect of effort-reward ratio on occupational well-being. Compared with the rural teachers who had lower over-commitment, effort-reward ratio was a stronger predictor of occupational well-being among rural teachers who had higher overcommitment. These results may contribute to the test of Price-Muller turnover model and the new effort-reward imbalance model,and have important reference value for reducing the turnover intention of rural teachers.