This article aims to investigate the learning outcomes of PBL on a medical affairs management program of a local medical college and to analyze students' response to this type of learning. A total of 24 students participated in the study and took part in the application of PBL to their medical affairs management classes. Learning results before and after classes were analyzed. Before commencement of each classe, the studentswere providedwith the subjectmatter and an instructor togetherwith the students determined the topic of the project. During the program, the students had to take turns to prepare class reports and these were discussed in small groups, and after each class, a structured questionnaire study was performed. Results showed that compared to traditional learning methods, 67% of the students were satisfied with this type of learning; 88% showed a considerable degree of acceptance of the division into small groups (4-5 persons per group); 67% of the students found they could absorb comprehensive knowledge through PBL and that learning was no longer unilateral, while 75% of the students felt that PBL was able to enhance their learning ability. Analysis of these results proved that this type of learning had a positive effect on the students' learning, as it increased students' initiative and improved teamwork. However, 71% said that PBL classes applied more pressure to them than classes where traditional learning methods were used. Because they had to invest more time in collecting information, 54% of the students felt it resulted in them spending less time on other classes. Among the teachers, on the other hand, only some 67% were satisfied with the PBL program and only those with a longer service record showed a level of satisfaction exceeding 90%, while the level of satisfaction for all other teachers did not even reach 50%, proving that teacher training requires continued attention.