Teacher professional development is one of the key elements for curriculum and teaching reforms. Facilitating curriculum reform and teacher professional development through university and school partnerships is a notable trend in Hong Kong. The Partnership for Improvement of Learning and Teaching (PILT) project is an example of such a partnership, sponsored by the Education Bureau. It aims at providing professional support for teachers in different Key Learning Areas and improving their teaching effectiveness and professional competence. A 4-P Model is employed by the project to enhance teachers’ reflection and professional growth. Based on the experiences of PILT, this paper discusses the operation of university-school partnership and the application of 4-P Model into a subject to improve teachers’ teaching practice, to promote their professional growth, and to nurture a professional community. Suggestions for future development of the 4-P Model and the PILT project are also put forward.