The purpose of this study was to explore the learning outcome of vocational special education students with the teaching strategy of "Combining Situated Learning Theory with E-learning", as well as the opinions of experimental group students toward E-learning. Using the class as a unit, the students were divided into two groups: the experimental and control group. Students in both groups took the pretest and posttest about learning achievement and motivation. After 8 weeks of the experiment, the data collected was statistically analyzed with pretest score as covariance and conducted a one-way ANCOVA analysis. Finally, the researchers conducted the questionnaire survey to determine the opinions of the experimental group students on the combination of situational learning and E-learning. The results indicated that using the teaching strategies for "Combining Situated Learning Theory with E-learning", the achievement and motivation were significantly better than with traditional teaching methods. Students had good results in retention after E-learning. At the same time,the experimental group students positive attitude toward E-learning.