While briefly introducing Mencius, Wang Yang-ming and Mo Zong-san’s definitions and comprehensions of “wisdom,” the main purpose of this paper is to interpret further issues like “the saint king”, “the self-negation of wisdom.” “The culture of wisdom” is a critical issue that is urgent and challenging for the development of Confucianism in the future, which widely covers modern issues such as science and democracy. This paper is a succinct preliminary reflection from a general perspective.