In the face of increased intensity and acceleration of global competition and knowledge economics, Taiwan is challenged by its ability to innovate through R&D and to attract talented people in a sustainable environment. For the past 30 years, Hsinchu Science Park (HSP) played a leading role in Taiwan's high-tech industry development. It, however, needs to be upgraded to maintain its competitive advantage. This research interviews experts from government, academic and industry, and to, benchmark HSP with other research parks overseas. It proposes a science park cluster network model and using SWOT analysis to evaluate HSP's current strategic position. HSP is strong in its innovative enterprises and support endowment in a global value chain niche position. Even it has strong knowledge producing institutions they are not fully integrated to form a dynamic innovative cluster network. HSP needs a research park as the innovation engine to integrate those R&D resources to increase its synergy and competitiveness, and to upgrade it into the HSP 2.0. This study also uses the UNISON model to propose a blueprint for the research park.