Since the mid-Ming period, the spirit-writing cult of Lüzu (or Ancestor Lü Dongbin) has been so popular within the Daoist milieu that it was regarded as the mainstream development of Daoism in the past few centuries. In other words, Lüzu’s spirit-writing cult has been one of the main features of Daoist development since mid-Ming times. This paper focuses on exploring the overall development of Lüzu’s spirit-writing cult from the late Ming Wanli reign (1573–1620) to the Qing Jiaqing reign (1796–1820). The present study shows that Lüzu’s spirit-writing cult in this specified period was in general characterized by four religious features. First, religious groups and spirit-writing altars were established by devotees of Lüzu, the Transcendent Lord of Spirit Writing. Secondly, these devotees of Lüzu’s spirit-writing altars were mostly Confucian scholars who piously practised Lüzu’s cult, rather than traditional Daoist priests or ministers. Thirdly, to save mankind, Lüzu, as commanded by superior celestial Lords of Dao such as the Heavenly Worthy of Primordial Beginning (Yuanshi tianzun 元始天尊), the Jade Emperor (Yühuang shangdi 玉皇上帝) or the Supreme Lord Laozi (Taishang daozu 太上道祖), descended frequently to various spiritwriting altars to teach Daoist scriptures (i.e. the so-called “feiluan xinghua” 飛鸞行化 [to convert people by spirit writing] or “chuijing chanjiao” 垂經闡教 [to teach people through revealing scriptures]). And fourthly, with the increasing popularity of Lüzu’s spirit-writing altars since the Ming-Qing era, the immortal Lü Dongbing won his obvious and continual promotion in the celestial rank as a result of his devotees’ worship. This research is based on the extant collections of multiple Lüzu scriptures that emerged from Lüzu’s spirit-writing altars throughout China from the Ming Wanli period to the Qing dynasty. A holistic perspective is adopted to collect, arrange, and analyse these materials so as to explore the general historical context in which Lüzu’s spirit-writing cult developed in the Ming-Qing era and to study the related literati spirit-writing groups. Besides, through investigating how devotees of Lüzu’s spirit-writing altars in different places continuously built up Lüzu’s spirit-writing cult, this paper reveals how Lüzu’s celestial status and divine connotations had been promoted and expanded continually at these altars during the period 1573–1820. It is worth noting that the literature involved in this part of the discussion includes nineteen pieces of “Lüzu gao” 呂祖誥 (Lüzu’s Spirit-altar Transcript) the author gathered from different editions of Lüzu quanshu 呂祖全書 (Complete Writings of Ancestor Lüzu). Lastly, this paper will discuss the underlying reason the Qing imperial court conferred on Lüzu the title “Xieyuan zanyun chunyang yanzheng jinghua fuyou dijun” 燮元 贊運純陽演正警化孚佑帝君 and included him in the official worship in the ninth year of the Jiaqing reign (1805), which led to an empire-wide worship (tongsi 通祀) of Lüzu as ordained by the Ministry of Rites. The author concludes that the authorized worship of Lüzu at the official and local levels in the Qing dynasty was the result of a boom in the popularity of Lüzu’s spirit-writing cult during the period 1573–1820.