This paper defines the main city of Marquez's novel, Macondo, with its main family, the Buendias, as a symbol of emergent post-colonial nations characteristic of those which have been exploited by capitalists, although it is also identified as Colombia and even to Latin America by some critics. This paper also investigates the relation of the destruction of the city and the causes which include the corruption of the local government, exploitation of the dominated by new elites and foreign capitalists, class struggles, ruthless killings in civil wars, repeated incest, ehnocentrism, and others. This paper concludes that merely such gestures as naming, myth-making, the construction of the origin of nationalism and essentialism cannot guarantee the survival of an emergent city/nation, for a post-colonial nation can never survive if it neglects practices to ensure strong internal unification, brotherhood, a common cultural foundation, and the people's awareness and precautions against insidious foreign economic invasion. Macondo is destined to die, for its inhabitants are ignorant of these practices.