This study analyzed and synthesized findings from selected studies conducted from 2003 through 2012 regarding effects of school sexuality education on students' sexual knowledge in Taiwan. Twenty-six papers were included in the meta-analysis and weighted effect size of Hedges and Olkin were compared between the experimental groups and the controlled groups. The analyses show that the weighted average effect size on sexual knowledge of the experimental groups is statistically higher than that of the controlled groups. The moderator analyses indicate that all independent variables regarding sexual knowledge except time of interventions were significantly related to the effects of school sexuality education on students' sexual knowledge. The results of this study will provide some suggestions for government authorities, elementary and secondary school leaders and teachers, and ongoing studies on sexuality education.