MAOA基因T941G多態性與同伴侵害對男青少年早期抑郁的交互作用：COMT基因Val158Met多態性的調節效應_

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題名：	MAOA基因T941G多態性與同伴侵害對男青少年早期抑郁的交互作用：COMT基因Val158Met多態性的調節效應
書刊名：	心理學報
作者：	曹叢／王美萍／曹衍淼／紀林芹／張文新
出版日期：	2017
卷期：	2017(2)
頁次：	206-218
主題關鍵詞：	MAOA基因；COMT基因；同伴侵害；抑郁；多基因-環境交互作用；MAOA gene；COMT gene；Peer victimization；Depressive symptoms；Multi-genes by environment interaction
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:0 共同引用:3 點閱:5

抑郁具有復雜的多基因遺傳基礎,然而既有研究大多采用單基因以及單基因-環境交互設計(G×E)考察抑郁的遺傳機制。以757名男青少年為被試(初次測評時Mage=11.32歲,SD=0.49歲),采用多基因-環境交互(G×G×E)設計,本研究考察了MAOA(monoamine oxidase A,單胺氧化酶A)基因T941G多態性、COMT(catechol-O-methyltransferase,兒茶酚胺氧位甲基轉移酶)基因Val158Met多態性與同伴侵害對青少年早期抑郁的影響。結果顯示,MAOA基因T941G多態性與同伴侵害交互作用于青少年抑郁,同伴侵害僅顯著正向預測G等位基因(而非T等位基因)青少年抑郁。而且,MAOA基因T941G多態性與同伴侵害的交互作用受到COMT基因Val158Met多態性的調節,上述交互作用僅存在于COMT Met等位基因而非Val/Val基因型攜帶者中。研究結果顯示,抑郁的產生與個體差異存在多基因與環境間的復雜交互機制。

以文找文

The monoamine oxidase A(MAOA) gene, as an important candidate gene of depressive symptoms, has been demonstrated to interact with environmental factors, especially stressful life events and family environments, in predicting adolescent depressive symptoms. Peer victimization serves as a significant source of stress particularly during early adolescence and can lead to a series of psychosocial adjustment problems that even persist long after the experience of being harassed. However, it still remains unknown about whether or not the MAOA gene interacts with peer victimization on adolescent depressive symptoms. There is evidence about the significant interaction between the catechol-O-methyltransferase(COMT) gene and the MAOA gene on depressive symptoms. However, whether or not the COMT gene plays a moderating role on the interactive effects between MAOA gene and environmental factors is still unclear. Therefore, the present study aimed to examine(i) the interaction between the MAOA T94 G polymorphism and peer victimization on adolescent depressive symptoms and(ii) the moderating role of the COMT Val158 Met polymorphism in the aforementioned associations.The original participants(1440 adolescents, male = 757, 52.6%) was drawn from an ongoing longitudinal study, which recruiting children from 40 classes of 14 primary schools in Jinan, China. Because of the uncertainX-inactivation and resulting MAOA activity among females, this study limited our analyses on the male subsample. Using a 2-year longitudinal design, we first assessed adolescent depressive symptoms and peer victimization by self-rated Children’s Depression Inventory(CDI) and Peer Victimization Scale(PVS), respectively, at Time 1(Mage = 11.32 years, SD = 0.49). At time 2(Mage = 12.32 years, SD = 0.48), saliva samples of adolescents were collected and genotyped for the MAOA T941 and COMT Val158 Met polymorphisms using the Mass ARRAY Typer software version 3.4(Sequenom), and adolescent depressive symptoms were tested again using CDI. A series of hierarchical regressions were conducted to analyze the effects of genes and peer victimization on adolescent depressive symptoms. The results showed that, after depressive symptoms at Time 1 was controlled for, the MAOA T941 G polymorphism significantly interacted with peer victimization(i.e., physical victimization and relational victimization, respectively) in predicting depressive symptoms at Time 2. Among MAOA G allele carriers, peer victimization positively predicted depressive symptoms; however, among MAOA T allele carriers, peer victimization was not associated with depressive symptoms. More importantly, this interaction between the MAOA gene and peer victimization was moderated by the COMT Val158 Met polymorphism, such that the aforementioned interaction only existed among COMT Met allele carriers, but not among Val/Val homozygotes. That is, among all combined genotypes of the MAOA and COMT genes, only G-Met genotype carriers were susceptible to peer victimization. In summary, our results demonstrated that peer victimization also served as an important candidate environmental factor and interacted with the MAOA gene in predicting depressive symptoms during early adolescence. Of particular note, such interactive effect between the MAOA gene and peer victimization was further moderated by the COMT Val158 Met polymorphism. These findings highlight the importance of investigating the moderating role of peer victimization in the association between genes and depressive symptoms during early adolescence. More importantly, this study underscores complex polygenic underpinnings of depressive symptoms and lends support for the multi-genes by environment interactions on the etiology of depressive symptoms.

以文找文

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