MAOA基因T941G多態性與同伴侵害對男青少年早期抑郁的交互作用：COMT基因Val158Met多態性的調節效應_

:::

詳目顯示

第 1 筆 / 總合 1 筆

/1頁

來源文獻資料
摘要
外文摘要
引文資料

題名：	MAOA基因T941G多態性與同伴侵害對男青少年早期抑郁的交互作用：COMT基因Val158Met多態性的調節效應
書刊名：	心理學報
作者：	曹叢／王美萍／曹衍淼／紀林芹／張文新
出版日期：	2017
卷期：	2017(2)
頁次：	206-218
主題關鍵詞：	MAOA基因；COMT基因；同伴侵害；抑郁；多基因-環境交互作用；MAOA gene；COMT gene；Peer victimization；Depressive symptoms；Multi-genes by environment interaction
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:0 共同引用:3 點閱:4

抑郁具有復雜的多基因遺傳基礎,然而既有研究大多采用單基因以及單基因-環境交互設計(G×E)考察抑郁的遺傳機制。以757名男青少年為被試(初次測評時Mage=11.32歲,SD=0.49歲),采用多基因-環境交互(G×G×E)設計,本研究考察了MAOA(monoamine oxidase A,單胺氧化酶A)基因T941G多態性、COMT(catechol-O-methyltransferase,兒茶酚胺氧位甲基轉移酶)基因Val158Met多態性與同伴侵害對青少年早期抑郁的影響。結果顯示,MAOA基因T941G多態性與同伴侵害交互作用于青少年抑郁,同伴侵害僅顯著正向預測G等位基因(而非T等位基因)青少年抑郁。而且,MAOA基因T941G多態性與同伴侵害的交互作用受到COMT基因Val158Met多態性的調節,上述交互作用僅存在于COMT Met等位基因而非Val/Val基因型攜帶者中。研究結果顯示,抑郁的產生與個體差異存在多基因與環境間的復雜交互機制。

以文找文

The monoamine oxidase A(MAOA) gene, as an important candidate gene of depressive symptoms, has been demonstrated to interact with environmental factors, especially stressful life events and family environments, in predicting adolescent depressive symptoms. Peer victimization serves as a significant source of stress particularly during early adolescence and can lead to a series of psychosocial adjustment problems that even persist long after the experience of being harassed. However, it still remains unknown about whether or not the MAOA gene interacts with peer victimization on adolescent depressive symptoms. There is evidence about the significant interaction between the catechol-O-methyltransferase(COMT) gene and the MAOA gene on depressive symptoms. However, whether or not the COMT gene plays a moderating role on the interactive effects between MAOA gene and environmental factors is still unclear. Therefore, the present study aimed to examine(i) the interaction between the MAOA T94 G polymorphism and peer victimization on adolescent depressive symptoms and(ii) the moderating role of the COMT Val158 Met polymorphism in the aforementioned associations.The original participants(1440 adolescents, male = 757, 52.6%) was drawn from an ongoing longitudinal study, which recruiting children from 40 classes of 14 primary schools in Jinan, China. Because of the uncertainX-inactivation and resulting MAOA activity among females, this study limited our analyses on the male subsample. Using a 2-year longitudinal design, we first assessed adolescent depressive symptoms and peer victimization by self-rated Children’s Depression Inventory(CDI) and Peer Victimization Scale(PVS), respectively, at Time 1(Mage = 11.32 years, SD = 0.49). At time 2(Mage = 12.32 years, SD = 0.48), saliva samples of adolescents were collected and genotyped for the MAOA T941 and COMT Val158 Met polymorphisms using the Mass ARRAY Typer software version 3.4(Sequenom), and adolescent depressive symptoms were tested again using CDI. A series of hierarchical regressions were conducted to analyze the effects of genes and peer victimization on adolescent depressive symptoms. The results showed that, after depressive symptoms at Time 1 was controlled for, the MAOA T941 G polymorphism significantly interacted with peer victimization(i.e., physical victimization and relational victimization, respectively) in predicting depressive symptoms at Time 2. Among MAOA G allele carriers, peer victimization positively predicted depressive symptoms; however, among MAOA T allele carriers, peer victimization was not associated with depressive symptoms. More importantly, this interaction between the MAOA gene and peer victimization was moderated by the COMT Val158 Met polymorphism, such that the aforementioned interaction only existed among COMT Met allele carriers, but not among Val/Val homozygotes. That is, among all combined genotypes of the MAOA and COMT genes, only G-Met genotype carriers were susceptible to peer victimization. In summary, our results demonstrated that peer victimization also served as an important candidate environmental factor and interacted with the MAOA gene in predicting depressive symptoms during early adolescence. Of particular note, such interactive effect between the MAOA gene and peer victimization was further moderated by the COMT Val158 Met polymorphism. These findings highlight the importance of investigating the moderating role of peer victimization in the association between genes and depressive symptoms during early adolescence. More importantly, this study underscores complex polygenic underpinnings of depressive symptoms and lends support for the multi-genes by environment interactions on the etiology of depressive symptoms.

以文找文

期刊論文
1.	Mynard, H.、Joseph, S.(2000)。Development of the Multidimensional Peer-Victimization Scale。Aggressive Behavior，26(2)，169-178。
2.	Beach, S. R. H.、Brody, G. H.、Gunter, T. D.、Packer, H.、Wernett, P.、Philibert, R. A.(2010)。Child maltreatment moderates the association of MAOA with symptoms of depression and antisocial personality disorder。Journal of Family Psychology，24(1)，12-20。
3.	Benjamin, D.、van Bakel, I.、Craig, I. W.(2000)。A novel expression based approach for assessing the inactivation status of human X-linked genes。European Journal of Human Genetics，8(2)，103-108。
4.	Carrel, L.、Willard, H. F.(2005)。X-inactivation profile reveals extensive variability in X-linked gene expression in females。Nature，434(7031)，400-404。
5.	Chen, J.、Li, X.、McGue, M.(2012)。Interacting effect of BDNF Val66Met polymorphism and stressful life events on adolescent depression。Genes, Brain and Behavior，11(8)，958-965。
6.	Comasco, E.、Sylvén, S. M.、Papadopoulos, F. C.、Sundström-Poromaa, I.、Oreland, L.、Skalkidou, A.(2011)。Postpartum depression symptoms: A case-control study on monoaminergic functional polymorphisms and environmental stressors。Psychiatric Genetics，21(1)，19-28。
7.	Gong, P. Y.、Xi, S. M.、Shen, G. M.、Li, S.、Zhang, P. Z.、Cao, G. C.、Ma, H.(2013)。The effects of DBH, MAOA, and MAOB on attentional biases for facial expressions。Journal of Molecular Neuroscience，49(3)，606-613。
8.	Hotamisligi, G. S.、Breakefiedl, X. O.(1991)。Human monoamine oxidase A gene determines levels of enzyme activity。American Journal of Human Genetics，49(2)，383-392。
9.	Larson, C. L.、Taubitz, L. E.、Robinson, J. S.(2010)。MAOA T941G polymorphism and the time course of emotional recovery following unpleasant pictures。Psychophysiology，47(5)，857-862。
10.	Evans, M. G.(1985)。A Monte Carlo study of the effects of correlated method variance in moderated multiple regression analysis。Organizational Behavior and Human Decision Processes，36(3)，305-323。
11.	紀林芹、陳亮、徐夫真、趙守盈、張文新(2011)。童年中晚期同伴侵害對兒童心理社會適應影響的縱向分析。心理學報，43(10)，1151-1162。延伸查詢
12.	曹叢、陳光輝、王美萍、曹衍淼、張文新(2014)。MAOA基因與抑鬱的關係。心理科學進展，22(12)，1899-1910。延伸查詢
13.	Baker, M.、Dorzab, J.、Winokur, G.、Cadoret, R.(1972)。Depressive disease: Evidence favoring polygenic inheritance based on an analysis of ancestral cases。Archives of General Psychiatry，27(3)，320-327。
14.	Belsky, J.、Beaver, K. M.(2011)。Cumulative-genetic plasticity, parenting and adolescent self-regulation。Journal of Child Psychology and Psychiatry，52(5)，619-626。
15.	Doornbos, B.、Dijck-Brouwer, D. A. J.、Kema, I. P.、Tanke, M. A. C.、van Goor, S. A.、Muskiet, F. A. J.、Korf, J.(2009)。The development of peripartum depressive symptoms is associated with gene polymorphisms of MAOA, 5-HTT and COMT。Progress in Neuro-Psychopharmacology and Biological Psychiatry，33(7)，1250-1254。
16.	Dunn, E. C.、Uddin, M.、Subramanian, S. V.、Smoller, J. W.、Galea, S.、Koenen, K. C.(2011)。Research review: Gene-environment interaction research in youth depression--a systematic review with recommendations for future research。Journal of Child Psychology and Psychiatry，52(12)，1223-1238。
17.	Felten, A.、Montag, C.、Markett, S.、Walter, N. T.、Reuter, M.(2011)。Genetically determined dopamine availability predicts disposition for depression。Brain and Behavior，1(2)，109-118。
18.	Peyrot, W. J.、Milaneschi, Y.、Abdellaoui, A.、Sullivan, P. F.、Hottenga, J. J.、Boomsma, D. I.、Penninx, B. W. J. H.(2014)。Effect of polygenic risk scores on depression in childhood trauma。The British Journal of Psychiatry，205(2)，113-119。
19.	Caspi, A.、McClay, J.、Moffitt, T. E.、Mill, J.、Martin, J.、Craig, I. W.、Poulton, R.(2002)。Role of genotype in the cycle of violence in maltreated children。Science，297(5582)，851-854。
20.	曹叢、王美萍、紀林芹、魏星、曹衍淼、張文新(20160100)。MAOA基因Rs6323多態性與母親支持性教養對青少年抑鬱的交互作用：素質--壓力假說與不同易感性假說的檢驗。心理學報，48(1)，22-35。延伸查詢
21.	Banny, A. M.、Cicchetti, D.、Rogosch, F. A.、Oshri, A.、Crick, N. R.(2013)。Vulnerability to depression: A moderated mediation model of the roles of child maltreatment, peer victimization, and serotonin transporter linked polymorphic region genetic variation among children from low socioeconomic status backgrounds。Development and Psychopathology，25(3)，599-614。
22.	Benjet, C.、Thompson, R. J.、Gotlib, I. H.(2010)。5-HTTLPR moderates the effect of relational peer victimization on depressive symptoms in adolescent girls。Journal of Child Psychology and Psychiatry and Allied Disciplines，51(2)，173-179。
23.	Sugimura, N.、Rudolph, K. D.(2012)。Temperamental differences in children's reactions to peer victimization。Journal of Clinical Child & Adolescent Psychology，41(3)，314-328。
24.	Hawk, D. S. J.、Boulton, M. J.(2000)。Twenty years' research on peer victimization and psychosocial maladjustment: a meta-analytic review of cross-sectional studies。Journal of Child Psychology and Psychiatry，41(4)，441-455。
25.	Cicchetti, D.、Rogosch, F. A.、Sturge-Apple, M. L.(2007)。Interactions of child maltreatment and serotonin transporter and monoamine oxidase A polymorphisms: Depressive symptomatology among adolescents from low socioeconomic status backgrounds。Development and Psychopathology，19，1161-1180。
26.	Drabant, E. M.、Hariri, A. R.、Meyer-Lindenberg, A.、Munoz, K. E.、Mattay, V. S.、Kolachana, B. S.、Weinberger, D. R.(2006)。Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation。Archives of General Psychiatry，63，1396-1406。
27.	Dunn, E. C.、Brown, R. C.、Dai, Y.、Rosand, J.、Nugent, N. R.、Amstadter, A. B.、Smoller, J. W.(2015)。Genetic determinants of depression: Recent findings and future directions。Harvard Review of Psychiatry，23，1-18。
28.	Eisenhofer, G.、Finberg, J. P.(1994)。Different metabolism of norepinephrine and epinephrine by catechol-Omethyltransferase and monoamine oxidase in rats。Journal of Pharmacology and Experimental Therapeutics，268，1242-1251。
29.	Forbes, E. E.、Dahl, R. E.(2012)。Research Review: Altered reward function in adolescent depression: What, when and how?。Journal of Child Psychology and Psychiatry，53，3-15。
30.	Gohier, B.、Senior, C.、Radua, J.、El-Hage, W.、Reichenberg, A.、Proitsi, P.、Surguladze, S. A.(2014)。Genetic modulation of the response bias towards facial displays of anger and happiness。European Psychiatry，29，197-202。
31.	Gottfredson, N. C.、Foshee, V. A.、Ennett, S. T.、Haberstick, B.、Smolen, A.(2015)。Genetic heterogeneity in adolescents' depressive symptoms in response to victimization。Journal of Clinical Child & Adolescent Psychology，44，762-774。
32.	Jabbi, M.、Kema, I. P.、van der Pompe, G.、te Meerman, G. J.、Ormel, J.、den Boer, J. A.(2007)。Catechol-omethyltransferase polymorphism and susceptibility to major depressive disorder modulates psychological stress response。Psychiatric Genetics，17，183-193。
33.	Januar, V.、Saffery, R.、Ryan, J.(2015)。Epigenetics and depressive disorders: A review of current progress and future directions。International Journal of Epidemiology，44，1364-1387。
34.	Lachman, H. M.、Papolos, D. F.、Saito, T.、Yu, Y. M.、Szumlanski, C. L.、Weinshilboum, R. M.(1996)。Human catechol-O-methyltransferase pharmacogenetics: Description of a functional polymorphism and its potential application to neuropsychiatric disorders。Pharmacogenetics and Genomics，6，243-250。
35.	LaFontana, K. M.、Cillessen, A. H. N.(2010)。Developmental changes in the priority of perceived status in childhood and adolescence。Social Development，19(1)，130-147。
36.	Lancaster, T. M.、Linden, D. E.、Heerey, E. A.(2012)。COMT val158met predicts reward responsiveness in humans。Genes, Brain and Behavior，11，986-992。
37.	Mandelli, L.、Serretti, A.(2013)。Gene environment interaction studies in depression and suicidal behavior: An update。Neuroscience & Biobehavioral Reviews，37(10)，2375-2397。
38.	Papaleo, F.、Crawley, J. N.、Song, J.、Lipska, B. K.、Pickel, J.、Weinberger, D. R.、Chen, J. S.(2008)。Genetic dissection of the role of catechol-O-methyltransferase in cognition and stress reactivity in mice。The Journal of Neuroscience，28，8709-8723。
39.	Plomin, R.(2013)。Child development and molecular genetics: 14 years later。Child Development，84，104-120。
40.	Proitsi, P.、Lupton, M. K.、Reeves, S. J.、Hamilton, G.、Archer, N.、Martin, B. M.、Powell, J. F.(2012)。Association of serotonin and dopamine gene pathways with behavioral subphenotypes in dementia。Neurobiology of Aging，33，791-803。
41.	Qian, Q. J.、Yang, L.、Wang, Y. F.、Zhang, H. B.、Guan, L. L.、Chen, Y.、Faraone, S. V.(2010)。Gene-gene interaction between COMT and MAOA potentially predicts the intelligence of attention-deficit hyperactivity disorder boys in China。Behavior Genetics，40，357-365。
42.	Rice, F.、Harold, G.、Thapar, A.(2002)。The genetic aetiology of childhood depression: A review。Journal of Child Psychology and Psychiatry，43，65-79。
43.	Roy, M.、Tapadia, M. G.、Joshi, S.、Koch, B.(2014)。Molecular and genetic basis of depression。Journal of Genetics，93，879-892。
44.	Rudolph, K. D.、Troop-Gordon, W.、Hessel, E. T.、Schmidt, J. D.(2011)。A latent growth curve analysis of early and increasing peer victimization as predictors of mental health across elementary school。Journal of Clinical Child & Adolescent Psychology，40，111-122。
45.	Troop-Gordon, W.、Rudolph, K. D.、Sugimura, N.、Little, T. D.(2015)。Peer victimization in middle childhood impedes adaptive responses to stress: A pathway to depressive symptoms。Journal of Clinical Child & Adolescent Psychology，44，432-445。
46.	王美萍、紀林芹、張文新(2015)。MAOA基因rs6323多態性與同伴關係對男青少年早期抑鬱的影響。心理學報，47，1260-1268。延伸查詢
47.	Benjamini, Y.、Hochberg, Y.(1995)。Controlling the false discovery rate: A practical and powerful approach to multiple testing。Journal of the Royal Statistical Society: Series B (Methodological)，57(1)，289-300。

圖書
1.	Kovacs, M.、Staff, M.(2003)。Children's Depression Inventory (CDI): Technical manual update。North Tonawanda, NY：Multi-Health Systems, Inc.。
2.	Cohen, Jacob E.(1988)。Statistical Power Analysis for the Behavioral Sciences。Lawrence Erlbaum Associates。

推文
推薦
引用網址
引用嵌入語法
轉寄

top

:::

相關期刊
相關論文
相關專書
相關著作
熱門點閱

1.	基因與環境的交互作用：來自差別易感性模型的證據
2.	NR3C1基因多態性及單倍型、父母教養方式對青少年焦慮障礙的影響
3.	DRD2基因TaqIA多態性與同伴侵害對青少年早期抑郁的交互作用
4.	MAOA基因Rs6323多態性與母親支持性教養對青少年抑鬱的交互作用：素質-壓力假說與不同易感性假說的檢驗

無相關博士論文

無相關書籍

無相關著作

1.	心理學專業"實驗心理學"本科教學現狀的調查與分析
2.	權力、任務框架對自我和為他人決策時風險偏好的影響
3.	社會認同對流動兒童學業求助的影響
4.	基本需要滿足對遊戲滿意度的影響：沉醉感和積極情緒的序列中介作用
5.	羞怯與敵對的關係：同伴侵害和偏執的複合中介效應
6.	目標刺激運動特徵對自閉癥譜系障礙兒童平滑追蹤眼動的影響
7.	組織員工的工作疏離感：人格特質與工作特徵的交互效應
8.	組織危機溝通回應策略對員工情緒和行為的影響
9.	消極情緒抑制了老年人的口語產生過程
10.	大學生生涯適應力與創業效能感和創業意向的關係
11.	高中生內隱、外顯成就動機與學業拖延的關係
12.	中學生親子依戀對主觀幸福感的影響：師生關係及自尊的鏈式中介作用
13.	親子依戀、分離-個體化對大學生自我同一性狀態的影響：自我不一致的中介作用
14.	學習者控制和任務難度對多媒體學習的影響
15.	走神對中文閱讀績效的影響

QR Code

臺灣人文及社會科學引文索引資料庫系統

詳目顯示

臺灣人文及社會科學引文索引資料庫