NR3C1基因多態性及單倍型、父母教養方式對青少年焦慮障礙的影響_

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題名：	NR3C1基因多態性及單倍型、父母教養方式對青少年焦慮障礙的影響
書刊名：	心理學報
作者：	周雅／范方／彭婷／李媛媛／龍可／周潔瑩／梁穎欣
出版日期：	2017
卷期：	2017(10)
頁次：	1287-1301
主題關鍵詞：	焦慮障礙；糖皮質激素受體基因；教養方式；基因-環境交互作用；Anxiety disorders；Glucocorticoid receptor gene；Parenting styles；Gene-environment interaction
原始連結：	連回原系統網址
相關次數：	被引用次數:期刊(0) 博士論文(0) 專書(0) 專書論文(0) 排除自我引用:0 共同引用:3 點閱:8

NR3C1參與HPA軸調節,與應激相關的身心疾病關系密切。以往針對NR3C1與焦慮障礙的研究基本以成人為考察對象,且大多關注負性生活事件等個體層面環境變量。本研究采用病例-對照設計,以238名青少年為被試(焦慮障礙117人,對照121人),旨在考察NR3C1常見位點rs6191、rs6196、rs41423247的多態性、單倍型以及父母不同類型教養方式對焦慮障礙的影響。結果表明rs6191 GG基因型、rs6196 AA基因型、rs41423247 GG基因型與低焦慮障礙風險相關。父母過多的過度保護與冷漠拒絕、父親過少的溫暖關懷可預測較高的焦慮障礙風險。rs41423247多態性與母親溫暖關懷存在交互作用:rs41423247 GG基因型只在母親溫暖關懷較多時能降低焦慮障礙風險,在母親溫暖關懷較少時與焦慮障礙并無顯著相關。此外,rs6191-rs6196-rs41423247構成的單倍型GAG與低焦慮障礙風險顯著關聯,TGC與高焦慮障礙風險顯著關聯,且二者與母親溫暖關懷、母親過度保護分別存在交互作用。未來可采用追蹤研究,從表觀遺傳層面探討教養方式與NR3C1影響焦慮障礙的內在機制。

以文找文

Glucocorticoid receptor gene(NR3 C1), one of the key genes involved in the HPA axis regulation, has been evidenced to have a role in various stress-related physical and mental illnesses. Previous studies concerning NR3 C1 polymorphisms and anxiety disorders, however, have mostly been conducted among adult samples and looked into negative environmental variables such as adverse or traumatic life events while examining the gene-environment interactions. There is a dearth of knowledge on how NR3 C1 polymorphisms could contribute to adolescent anxiety disorders. The purpose of this study was to examine the genetic variants in NR3 C1 and their interaction with paternal and maternal parenting styles in relationship to adolescent anxiety disorders using a Chinese sample. This study adopted a case-control design. Of 3501 adolescents underwent a stepwise clinical screening, 117 who were diagnosed with anxiety disorders(74 females; average age 16.69 ± 1.13 years) and 121 healthy controls(56 female; average age 16.54 ± 1.05 years) were included in this study. Participants’ oral mucosal samples were collected for DNA extraction and three single-nucleotide polymorphisms(SNPs) of the NR3 C1 gene(i.e., rs41423247, rs6191, rs6196) were genotyped using Mass ARRAY system. The Chinese version of Parental Bonding Instrument was used to measure four types of paternal/maternal parenting styles(i.e., warmth, autonomy, overprotection, indifference). Multivariate logistic regressions were performed to examine the main effects of genotypes and parental/maternal parenting styles and their interactions in predicting the presence of anxiety disorders. Results revealed that rs6191 GG genotype, rs6196 AA genotype and rs41423247 GG genotype were associated with decreased risk of anxiety disorders. Higher level of paternal/maternal overprotection and indifference, as well as lower level of paternal warmth, could predict increased risk of anxiety disorders. Moreover, there was a significant interaction between rs41423247 genotypes and maternal warmth in predicting adolescent anxiety disorders; that is, rs41423247 GG genotype was linked with reduced risk of anxiety disorders only when maternal warmth was high. Haplotype analysis revealed three haplotypes with frequencies of > 5%(rs6191-rs6196-rs41423247): GAG, TAC, and TGC. GAG and TGC were respectively associated with decreased and increased risk of anxiety disorders. Maternal warmth and overprotection were found to moderate these effects. GAG would reduce the risk of anxiety disorders only when maternal warmth was high, while TGC would enhance the risk only when maternal overprotection was high. This study is the first to investigate the role of NR3 C1 polymorphisms and parenting styles in anxiety disorders among Chinese adolescents. The findings on gene-environment interactions lend support to the vantage sensitivity hypothesis, which propose variation in people’s responsiveness to exclusively positive environmental influences as a function of individual endogenous characteristics. Future research on the epigenetic mechanisms underlying the relationship between NR3 C1, parenting styles and adolescent anxiety disorders is warranted, to further explore the disease etiology.

以文找文

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