This study explores the interaction effects of organizational factors and individual factors on safety performance. The researcher employed a questionnaire survey to attain this objective. The population was 560 managers and engineers in a TFT-LCD manufacturing industry in central Taiwan. A purposive sampling was used to select 360 subjects. The usable sample size was 168, yielding response rates of 57.22%. The researchers used a two-way multivariate analysis of variance (MANOVA) to analyze the data. The researchers found that there are significant interaction effects on safety performance between 1) units and seniority; 2) units and title; 3) units and accident experience. As such, whether or not individual perception of safety performance differs must be determined by the organizational factors. It is suggested that organizations like consider the internal and external factors simultaneously, and then will complete the organizational objective.