Literature not only inherits convention but also develops with time as species do. The development of both literary genres and species are influenced by time and space. In Chinese literature, the variety with time and space of Fu is remarkable. This article tries to examine the mutable genes of Fu by viewpoint of the species gene and mutation. It attempts to arrange new research skeleton, and refers to creative points of view, while also supplying a new indicator of the evolvement of FU in individual period. Literature is an art expressed by language and characters. M. H. Abrams designs four elements of art, universe, artist, work, and audience in The Mirror and Lamp. This article selects artist, work, and audience and “in which channel” and “with what effect” in Harold D. Lasswell formula (frequently used in mass media) to be the five pairs of chromosomes of literary genre varieties with time and space in order to examine the mutable gene. What are the chain varieties of the gene combination caused by the five pairs of chromosomes? The critical period of gene variety of Fu lies in East Han Dynasty. Genes may be operated by mutator genes and occurs copying mistakes. After examining the variety of Fu in individual periods, we find this mutator gene as species and understand the development of Fu usually becomes new combination different from parents by gene alteration as the tending to the same of species. The varieties of Fu in history may be understood through “recombination” as well. Then we will provide the main stream of Fu. It could be divided into three stages that include jester-literature of pre-Qin and West Han dynasty, scholar-literature of East Han and six Dynasty, and examination-literature of Tang and Sung Dynasty.