The aim of this paper is to investigate the conceptual significance of Nothingness in Wang Bi’s philosophy. Our research approach is hermeneutical and inter-cultural. From the point of comparative philosophy, to manifest the transformation of ancient Chinese philosophy in the modern intellectual context. We try to locate Wang Bi’s metaphysics of Nothingness by analyzing the different modern interpretations of Nothingness. This work can improve of the reflection on the concrete use and linguistic function of the language of the modern Chinese philosophy.