Japanese well-known artist Kusama Yayoi said: "If not for art, I should have committed suicide." It means that artistic can give a person the spiritual level of satisfaction and promotion, and even bring happiness to our lives. The purpose of this study was to explore the relationships among artistic and cultural activities, aesthetic experiences, and well-being for college students in Taiwan. The researchers adopted the method of survey and 513 valid questionnaires were retrieved from college students in northern Taiwan. Data were analyzed by independent sample t-test, one-way ANOVA, a Pearson's product-moment correlation, and a multiple stepwise regression analysis. In order to increase the ability of university students in Taiwan, this study provided some suggestions on the basis of the results for administrators of artistic and cultural activities, government, universities, and even future studies.