Despite being an important work of the Six Dynasty period written specifically to discuss the question of body and spirit (形神 xingshen), the Lishenming chengfo yiji 立神明成佛義記 by Emperor Wu of the Liang Dynasty 梁武帝 has not been given much attention by scholars. Here we attempt to analyze this work and show the following: 1.The mind (心 xin)or shenming (神明) seen by Emperor Wu as being the Buddha-nature (buddhadhātu) possessed by all people should not be understand in terms of something like a spirit or soul but rather as referring to mind essence (心性 xinxing). He holds that avidyā does not exist independently of shenming and that they are two different aspects - one polluted, the other pure - of the mind. A11coming into and passing out of being in the world are a function (用 yung) of the mind, while substance (體 ti) of the mind itself is immutable. In other words, he uses the substance-function dichotomy to link the mind with the real world and explain samsāra. 2. As with Fan Zhen 范縝 and his Shenmielun 神滅論, Emperor Wu employs the substance-function distinction to develop a theory of the unity of body and spirit. In addition, both Emperor Wu and Shen Ji 沈績, with his use of the Buddhist notion of bujibuli 不即不離, are improvements over Fan Zhen in terms of strengthening and employing the notion of substance-function. As such, these two could have played a critical role in the history of the development of the substance-function paradigm. Indeed, it could be said that Emperor Wu and Fan Zhen achieved the highest level of theoretical success in the body-spirit debate. 3. Emperor Wu substituted the notion of “Buddha-nature” for the earlier “eternalspirit” because of the tathāgatagarbha notion that the Buddha-nature is the origin of the manifestation of all aspects of existence. In a similar vein, the notion of the “eternal spirit” was put forward earlier with a view to providing a basis for the realization of Buddhahood. As such, it was an understandable and reasonable development for the “Buddha-nature” to replace the “eternal spirit,” a transition that is fully represented by Emperor Wu’s work. This work also closely corresponds to the Awakening of Faith in the Mahayana both in terms of its mode of thought and their date of completion, a fact that suggests that there may be some connection between the two and further that the Lishenming chengfo yiji may have played an important role in the development of substance-function thought in Chinese Buddhism.