This study focused on the learning efficacy by using the strategies of problem-directed inquiry and group collaboration for teachers college students at an astronomical museum. The researcher took students in his physics class as research subjects and used learning sheets designed by himself as the research instrument. The design of learning sheets was based on the following principles: (1) the researcher would take the full advantage of the resources at an astronomical museum and those display objects picked out to be learned would be highly connected to the materials taught in the researcher’s class; (2) hidden mathematics would be applied to the problems; (3) interesting games or experiments would be included; (4) creative thinking intelligence would be stressed; (5) affective learning would be emphasized. During the course of students’ learning, the researcher played the role as a guider. The whole process went very smoothly, and the results turned out to be quite satisfactory, especially in affective learning. These results showed that learning at the astronomical museum could cultivate students’ scientific literacy and promote their affective growth. Therefore, it is appropriate to incorporate the learning at an astronomical museum to the science curriculum of the teachers college. Thus, on the one hand, students can learn in a multiple environment; on the other hand, they can learn more about how to teach at a science museum, which would be useful for them to guide children to learn at a science museum in the future.