'The integration of Confucianism, Taoism, and Buddhism into the interpretation of I Ching' is an important landmark in the thoughts of Fang Yizhi (1611-1671) in his late years. Although there are numerous studies discussing this idea, few of them can interpret and analyze the meanings of it clearly and profoundly, and demonstrate the trajectory of this thought. As a result, this paper adopts the viewpoint of 'life practice', and analyzes how Fang Yizhi pursued self-peace through his spiritual self-awareness when facing the change of era. It describes how Fang Yizhi decided to choose 'the integration of Confucianism, Taoism, and Buddhism into the interpretation of I Ching' as the thought of his life practice when he faced adverse situations. The proposal of this viewpoint is helpful to the understanding towards 'the integration of Confucianism, Taoism, and Buddhism into the interpretation of I Ching.' While facing the dilemma between loyalty and filial piety, Fang Yizhi chose to be Taoist hermit, and later became a Buddhist monk. As a Confucianist, he was deeply anxious. His self-blame for the failure in the practice of loyalty and filial piety led him to probe into the learning handed down from generation to generation in Fang's family, which was Fang's thoughts on I Ching, thus he surpassed the boundaries among these three thoughts. Meanwhile, this paper describes the solemn anticipation of Fang Yizhi in his failures of being a loyal court official and a filial son, and his ideas which were strengthened to integrate the ideas of three thoughts and his spirit of that age in enduring his idea of overthrowing the rule of the Ching Dynasty.