Background: Spirituality is the essence of being human and the capacity to express caring for others. Emergency room (ER) nurses are required to deal regularly with patients in critical condition. Nourishing the spirituality of ER nurses is widely recognized as an important way to help nurses provide care to patients in clinics. However, few studies have explored the spiritual nature of ER nurses.Purpose: This study explored perceptions of spirituality among ER nurses.Methods: This study used a descriptive-qualitative design and purposive sampling; we recruited 15 ER nurses as participants and collected data using face-to-face, semi-structured interviews; Tesch's qualitative data analysis was employed to analyze data. Results: Nurse perceptions of spirituality were classified into 3 dimensions with 9 subthemes, namely (1) "an inner force" (with the 4 subthemes of real spiritual power, indescribable abstract state, change comes agonizingly slowly, and healing power), (2) "the value and mission of a jointly shaped one and the other" (with the 2 subthemes of making good use of one's ability and satisfying others to enrich oneself), and (3) "test of resilience" (with the 3 subthemes of being more responsible, interaction of sense and sensibility, and facing reality with reasons).Conclusions: This study introduced the idea of spirituality as an inner power as perceived by ER nurses. Findings may provide a basis for spiritual education in nursing schools and the workplace as well as suggest spiritual growth guidelines for nursing leaders and staffs.