Comes for a long time, the national resources unceasingly invest in various types of non-profit research and development (R&D) organizations, yet their achievements hardly reach the social and the government earnest anticipation. Accordingly, most domestic and international non-profit R&D organizations presently receive demands from the society and the government in advancing their management benefit, in the meantime the society and the government review the achievement evaluation system of regular budgets for non-profit R&D organizations. This is a global problem, besides involves financial independency and sustainable development of such organizations, and to unload the government financial burden. Therefore, this research discusses how to frame R&D behavior, intellectual property business model and its marketing activities in a non-profit R&D organization, also explains the influential characteristics of business model and marketing in this framework. Furthermore, takes the most prominent non-profit R&D organization in Taiwan - the Industrial Technology Research Institute (ITRI) as the example, explains how a non-profit R&D organization oneself can have the opportunity and ability to create economic value of its intellectual property. Consequently, this research provides the mechanism of practicing intellectual property economic value. If non-profit R&D organizations reform from the infrastructure, that will bring substantive benefit to Taiwan economic performance in the near future.