In fact, the so-called “Cheng-sheng-jhih-dao (way of sanctification)” was the discussion that expounded the quality of entirety of the study of Cheng-sheng-wei-ji (sanctification is for the true ego) of Confucianism for Erh-Chu. Developing from the existing alienation, Erh-Chu discussed that people were influenced by Ming-sin-bing-gen (fame-the seed of disease); therefore, he separated the study of Wei-ji-cheng-de (being for the true ego and achieving the virtue) into the statuses of “for speech and theory but not practice,”“for people but not for accomplishing oneself only,” and “stressing the knowledge but not fulfillment.” In this exposition, Erh-Chu made the correction for this “Wei-ren-jhih-syue (study of being for people);” it actually contained the concept of “therapeutics” deeply, and it could manage and treat the thought of “existing alienation” and be its therapy. Hence, this article cited its intention, and made the interpretation from the angle of “therapeutics.” Specifically, Erh-Chu's therapy for managing and treating Wei-syue-gong-li (doing the study was for (self) utilitarianism) emphasized making a resolution and taking action personally first; these were the positive attitude and practice of the main body to manage and treat Ming-sin-bring-gen (fame-the seed of disease). Secondly, reading the classics of sages. Erh-Chu indicated that the classics of sages were the good medicine to benefit the world, and the prescription to cure our own diseases. Third, the most important treatment was the consciousness and realization for the actual existing main body-conscience. Essentially, the existing alienation must return to the existence itself to achieve the real treatment. The way of knowing the real nature and establishing the foundation became Erh-Chu's gist of thinking afterward. For the labor of practice, the moral expansion of “You-ren-yi-sing (to follow the benevolence and righteousness from the heart)” and the introspection labor of main body of the style of “Wei-dao-rih-sun (to decrease the disturbance of ordinary knowledge day by day)” were where to proceed. The article hereby framed Erh-Chu's interpretation toward “Cheng-sheng-jhih-dao (way of sanctification)” from the aspects of “the development of treatment,”“the existing alienation,”“the attitude of treatment,”“the treatment of reading,”“the self-treatment of main body,” and “the labor of treatment.”