The purpose of this study is to observe whether pre-service teachers can successfully develop inquiry-based teaching knowledge and skills through the "methods course and educational practicum for teaching natural science" curriculum. Based on the curriculum, to explore the processes of their professional development. The subjects of this study were thirteen pre-service teachers majoring in Nature Science Education in a University of Education. Based on instructional theories, and with the use of case teaching videos, the authors attempted to observe and understand pre-service teachers’ changes in their designs of teaching plans, classroom teaching activities, and classroom management. Throughout the course, the pre-service teachers studied at first theoretical foundations of inquiry-based teaching, followed by watching case teaching videos, designing lesson plans, micro-teaching, and finally practice teaching in elementary schools. Meanwhile, the researchers collected data from a range of sources, including pre-service teachers learning portfolios, lesson plans, feedback sheets, videos of their classroom teaching, and interviews. These data were then analyzed, leading to the following assertions. First, pre-service teachers gained basic understanding of 5Why scaffolding guided questioning teaching and POE teaching method after studying the theoretical part in this course. They understand more about teaching after watching videos of examples on how to use inquiry-based teaching method during class. Second, pre-service teachers were able to design lesson plans, which were student-centered and relevant to students’ real life. Such inquiry-based teaching invoked students’ motivation and participation, enabling them to construct knowledge by themselves. Third, most of pre-service teachers considered their skills in asking good questions still lacking, even after they went through the teaching activities on inquiry science teaching methods. However, they were able to identify their shortcomings and to explore ways for further improvement. Fourth, all of the participating pre-service teachers agreed that studying inquiry-based teaching through watching videos of teaching examples could help them on the design of lesson plans and on science teaching practice. According to the results obtained, it is suggested that the video clips of teaching examples should be uploaded on the internet, making them easily accessible for pre-service teachers to use. In addition, pre-service teachers are encouraged to visit elementary schools to observe classroom teachers’ teaching, in order to improve their own classroom management skills.