Mucopolysaccharidosis is a congenital hereditary disease which produces pathological changes in cells, tissues, and organs, but no negative effects on intelligence. Past research has found that through physical education (PE) instruction, it is possible to improve the self-concept, intelligence, and social-emotional abilities of individuals with disabilities. This paper aims to investigate the potential impact of adapted PE instruction for students with mucopolysaccharidosis, thus addressing a relative lack of relevant literature. In addition, students' physical condition while walking distances and muscular strength while playing badminton were evaluated to provide feedback on effectiveness of the adapted PE programs designed by teachers. The results from the first year show that there was no obvious effect on badminton performance via an adapted PE program. However, significant progress on badminton shot distance and physical activity duration were observed in the second year. This paper suggests that, in cooperation with physicians, data such as exercise duration and distance, and heart rates for students with mucopolysaccharidosis can be collected using wearable devices, providing instant teaching feedback.