The rapid development of ICT (Information Communication Technology) and the gradually approving attitude towards learner-centered instruction have contributed to an e-learning environment in the 21st century. In accordance with the e-learning trend, the Ministry of Education (MOE) in Taiwan has organized a team, consisting of scholars in the field of library and information science as well as representatives from a technology company, to design and produce a set of e-learning materials for general education curriculum on library and information skills at college and university level. The fruits of this project were made public in early 2010. Furthermore, since July of 2010, Professor Mei-Mei Wu of the Graduate Institute of Library and Information Studies at National Taiwan Normal University has been supported by the MOE to organize a team with nine other teachers from different universities and colleges to promote the e-learning materials. The author of this paper has been one of the team members and has applied the e-learning materials to the asynchronous distance course “Use of Internet and Library Resources” offered in the fall semester of 2010 by the General Education Center of Jinwen University of Science and Technology. In this paper, based on the author’s experience in instructing the course, detailed teaching design, implementation, and effectiveness of applying the e-learning materials are described and analyzed, which may serve as useful reference for instructors who are interested in involving the materials in their courses.