Although the mortality rate of stroke is keep decline, stroke is still the one the major cause of death in Taiwan. With the era of ageing country, the victim of stroke is keeping increasing. The risk factors of stroke can be altered by health education. Early recognition of the stroke symptom can prompt rapid treatment. Intravenous thrombolysis is the only approved treatment in acute ischemic stroke onset within three hours, however, most of the stroke patients cannot reach the hospital within the golden three hours. Education is the most useful method to reduce the prehospital decreased and increase the treatment rate of intravenous thrombolysis. The working place of the modern physician is changing from hospital to community, and school is part of the community to achieve the patient centered care. Our study target is to use the innovative educational program to improve grade six student’s stroke literacy, including stroke risk factors, symptoms and treatment, to establish their health behavior. Via the co-learning, their parents can also improve their health behavior. Our study proved that the stroke literacy, risk factors, symptoms and treatment recognition in both the student and parent had significantly improved after intervention program. The program not only improved the correct treatment behavior, but also corrected the wrong behavior. The numbers of innovators and early adopters had been increased after the program. In the post-intervention survey, we had a high program satisfaction in both the students and parents. The program had successfully created a topic in stroke among students and their parents, which will lead to health behavior.