Throughout the history, scholars investigate Wang Bi already make great achievements. Based on “Lao-zi Zhu,” scholars incorporate Wang bi’s thoughts into Daojia of early Qin or even metaphysics. Nevertheless, the debate about the connotation of Wang bi’s thought does not quiet down yet when Wei Jin metaphysician discuss the topics as “communication of Confucianism and Daojia,” “annotation of I-Ching based on Lao-zi’s idea,” “zi-Jeng and Ming-Giao” and so on. Moreover, being a thinker who is particular about method and systematic thinking, we believe that Wang bi is not only an intermediary between Confucianism and Daojia but enthusiastic to assume his own character. Therefore, how to properly analyze the connotation of Wang bi’s “Lao-zi Zhu” becomes as important task. The researcher employs “thread of thought” as research method in order to present the issues of Wang bi’s thought vertically but not horizontally as habitually practice in the field. Thus, the issues discussed are aggregations of ideas with causality but not either-or among issues and categories. The motive of the thread development is not because of the time succession but the expansion of the meaning or the permeation into different domains. As mentioned above, this study will explore the development and connotation of thread of thought in Wang bi’s “Lao-zi Zhu” based on “contradiction of physical phenomenon,” “establishment of ontology,” and “practice of metaphysical rule.”