Purpose: The purpose of this study was to analyze and predict the pitcher's pitching strategy during the game of Japan team against Chinese Taipei in the first World Baseball Classic. Method: The approach of video tape observation was used to collect the necessary data. A computer program written by C language was utilized to run the results for Back-propagation neural network predict model. Results: 1. The Japanese pitcher in the total of 114 pitching balls pitched straight ball mostly (61.4%), and the slide ball (23.6%) was the second; 2. The cross direction pitching and the identical direction pitching showed the same percentage (45%), but the identical direction pitching had the higher possibility to touch the base; 3. The straight ball was the highest percentage used by Japanese pitchers in the first pitch, and the variant ball (87.5%) occurred more than the straight ball after the condition of two-strike and one-ball; 4. The Back-propagation neural network model for pitcher's pitching prediction showed rather good percentage (70%) to predict Japanese pitcher's pitching. Conclusion: The Japanese baseball pitchers had their unique pitching strategy, and the Back-propagation neural network prediction model obtained about 70% predict rate for predicting Japanese baseball pitcher's pitching.