With the perspective of metaphysical discourses, this study investigates the influence mysterious learning and pure conversation exert on the issue of body and spirit's appearance and disappearance in the Six Dynasties, and deepens understanding of related issues by exploring the contextual meaning of the successive ideas. The issue of body and spirit's appearance and disappearance can be traced back to the no-ghost theory and the dream theory, whose body and spirit concepts are significant references for later discussions. For analyzing and thinking, the concepts of "root and branch, existence and nonexistence," "views about nature," "body and function" in mysterious learning are often the most frequently applied pattern. Therefore, just as pure conversation has diverse forms of development in the Southern Dynasties, the issue of body and spirit's appearance and disappearance is also a composite thesis. It is the result of its former topics' mutual integration and interaction with Buddhist concepts.