The objective of this study was to investigate the effects of nursing instructions given to caregivers of long-term bedridden patients. Subjects included 392 caregivers whose patients met the criteria of grade 3-4 based on the Karnofsky scale. After caregivers were given nursing instructions, the public health nurses monitored the patients' progress once a month for three months. Three criteria were used to determine the instructions' effectiveness: degree of improvement of patients' self-care ability, change in the patient's condition with respect to pressure sores, and overall ability of caregivers (including caregiving knowledge and techniques for general care and care of pressure sores). All data were analyzed by SPSS and statistical methods including frequency, Chi-square test, t-test, paired t-test, and multiple logistic regression. Results showed a significant improvement in the overall ability after caregivers were given instructions. One third subjects with pressure sore was improved. The average score for self-care ability given to patients improved significantly over the three- month period, however this was not found to be related to the caregivers' ability. Based on a logistic egression analysis, bedridden duration and grade of mobility had a significant effect on the patient's self-care ability. The authors suggest that nursing instructions need to be provided to caregivers as early as possible in order to effectively improve the patient's self-care ability.