Compare to west countries, the history of emerging social work into hospital setting in Taiwan was relatively short and just reached 60th year. The current study intended to review the development process of medical social work profession via the introspection of social events and demonstration of practical actions, and further entrust with fresh ideas for the social work profession to enhance and inspire passion among social workers. Therefore, through the presenting, annotation, and innovation of the history, there were positive effects on the development of helping profession. The author first described the history and spirits of general social work, and then reviewed the literature on the history of medical social work, and further discussed the evolving the medical social work publication and research in Taiwan. Finally, the author focused on the major events and related issues before and after the Medical Social Work Association was formed in 1983. The purpose of this study was to foresee the future of social work profession in health care setting via close review and reflections of history along with the first-hand data and years of clinical experiences the author had in the field.