This paper consists of two parts for a comparison between Wang Chong's and Zhu Xi's notions of Kuei-Shen. The first part is an investigation from the background and purpose of the notion of Kuei-Shen, and also from the problem of the existence of Kuei-Shen, to indicate the similarities between Wang Chong and Zhu Xi in their anti-religious aims, and to point out how they share similar notions of Kuei-Shen because of the shared interpretative categories of Hun-Po and Kuei-Shen in Pre-Qin period. Kuei-shen However, due to different philosophical developments in different times, Wang Chong and Zhu Xi have different objects in their theories of Kuei-Shen, which can be seen in Wang Chong's prudence and Zhu Xi's toleration. The second part is an investigation from Wang Chong's and Zhu Xi's notions of Kuei-Shen in the historical context of Chinese philosophy, to set the notion of Kuei-Shen as an independent issue in Chinese philosophy, including metaphysical, religious, and normative perspectives, so as to examine the similarities and differences between the two. Both of them take Kuei-Shen to be a metaphysical issue in their own metaphysical system in responding to the religions of the time, intending to replace superstition by theories with some educative and normative significance. But there is a difference: Wang Chong is more negative towards education, whereas Zhu Xi is more positive.