It is a secular trend that museums become commercial by extending into the business world and connecting with private sectors. How the museums in Taiwan can identify and develop the relevant key success factors is a topic that deserves academic attention. This paper aims to explore the pertinent key success factors and determine their relative weights for museums to make inroads into the cultural and creative industry. The research scope is limited to public museums in Taiwan dedicated to art and humanity. The author applies the three-round Delphi technique and Analytic Hierarchy Process (AHP) by consulting 30 experts. Based on the surveyed results, this paper constructs the list of key success factors and determines the relative weights in the hierarchy for Taiwanese museums to enter the cultural and creative industry. A total of four dimensions, 13 criteria and 60 items are established. Among all the dimensions, customer services are the most important, followed by learning & innovation. Financial management is considered the least relevant. Among all the criteria, the enhancement of staff competences in the cultural and creative industry is rated as the most important. In general, talent development and recruitment are critical to the success of any museum planning to enter the cultural and creative industry. Finally, this paper presents its suggestions to decision-makers in museums and educational authorities.