By analyzing the meanings of the knowledge-based economy and the development of globalization, this paper aims to explore the possible model of on-the-job training for teachers in marginal regions of the knowledge-based economy. While the globalization process quickly spreads out all over the world it is safe to believe that the rise of the knowledge-based economy will enlarge the inequality between the poor and the rich. Those people who live in rural regions are more likely to be disadvantaged under the social changes that accompany globalization. In order to cope with the negative impact of globalization and the knowledge-based economy, educators in marginal areas must reflect upon the viewpoints of glocalization and localization. The viewpoints of glocalization and localization argue that local values and characters empower marginal groups to deal with the disadvantageous and difficult situations caused by the rise of the knowledge-based economy and globalization. The key concepts of glocalization and localization are coherent with the arguments of center-periphery theory. When applying the center-periphery theory in the practical field of education, local knowledge from the practitioners becomes valuable and important. According to center-periphery theory, the school-based curriculum development model allows that knowledge is derived from teachers' practical work in everyday life. Teachers' reflection on the global social change and the responsiveness of the marginal values and beliefs enrich teaching and learning. By doing so, teachers and educators are able to strengthen their professional development through daily work.