The purpose of the study was to find out how mothers of preschool children with disabilities to deal with parent-child conflict by using quantitative and qualitative methodologies. Samples were those mothers whose preschool children with disabilities in southern Taiwan. The quantitative sample size was 164 and qualitative samples size was 5. The questionnaire “the Inventory of Mother’s Coping Strategies of Parent-Child Conflict” was developed by the author and using quantitative data analyzed and MANOVA by SPSS 10.5 as data analysis tools. The major findings were as follows: 1. Mothers of preschool children with disabilities had significant differences when they deal with parent-child conflict. The cooperative strategy was used most. The compromising, forcing and accommodating strategies were in line with next. The least used strategy was avoiding strategy. 2. Mothers’ coping strategy of different type of disabled children only had significant differences in two parent-child conflict situations such as “dressing” and “shopping”. In “dressing” conflict situation, the development retarded children’s mothers significantly used accommodating strategy more than mothers of hard-of-hearing