Because of the human predicament and bereavement, Li Zhi came into contact with Confucianism, Buddhism and Taoism at the age of forty. Far from access to getting selected in the imperial examination, this contact, considered by Li Zhi as “learning the way of Dao” or “in search of Dao,” is actually an endeavor to comprehend life and death. He tries to grasp the meaning of life and death on the one hand and transcend it on the other hand since for him life is full of mundane plights and traps. Such a probing insight into the phenomenon of life and death results in his emphasis on the hardship in life rather than the sorrow in death. He laments the physical life which is deeply inseparable from the misfortunes, hence his contact with Confucianism, Buddhism and Taoism. Here, it would be proper to say that his exploration into these three domains is based on his understanding of the living and his preoccupation is invariably the phenomenon of life and death. So, how does he “locate one’s lifetime” in terms of the three religious domains? And following this, how should we interpret his death? This paper will try to answer these questions.