This study investigated professional empowerment of junior middle school teachers in Taiwan, compared the difference on the sense of autonomy in background variables, and explored the extent to which professional power explained professional efficacy, using questionnaire method. The results showed that (1)the sense of professional empowerment of junior middle school teachers was on the middle level, among which the individual teaching efficacy was the most positive, and the power of participating in decision-making was the most negative; (2)there was difference in the sense of professional empowerment of teachers from different background variables (gender, occupation, educational level, age, years of service, school location, size, history, and school district culture); (3)professional status and impact, individual teaching efficacy, and general self-efficacy could be effectively explained and predicted by teachers' power of participating in decision-making, teaching autonomy, and professional growth.