The aim of this study is to investigate v senior and vocational high school teachers' job stress, depression in Taipei City. and used Quota Sampling to do the survey. There were 582 valid questionnaires collected. Research instruments included Personal Background Questionnaire, Teachers Job Stress Scale, Taiwanese Depression Questionnaire. Data were analyzed using descriptive statistics, independent sample t-test, one-way ANOVA, Scheffe method, Pearson’s product-moment correlation, and multiple regression analysis. The major findings were as follows: The results showed that the job stress of Taipei high school vocational teachers tend to situations of low level, school level factors feelings maximum job stress. The job stress because of the different types and size of the school and there are significant differences exist. Depression because of the different types of schools and there are significant differences exist. Significant positive correlation between the degree of overall job stress and depression as a whole. According to the findings and conclusions of this study, we offer the following suggestions: “educational institutions” should give care, support, and assistance in real terms to teachers in order to increase confidence of teaching and to make progress toward correction and the positive development. In addition, health-related units should be invited to establish common medical care systems for teacher in order to improve physical and mental health of teachers, to create appropriate teaching and residential environments, and to organize a healthy lifestyle of leisure activities to enhance the quality of life of teachers.