Research indicates that interpersonal relationship is one of the major factors affecting the life-adjustment and learning of college students in Taiwan. A well-developed interpersonal relationship in college stages will help individuals to establish meaningful relationship in their adult lives. However, the development of interpersonal relationship is affected by individuals' personality and interpersonal communication. The purpose of this study is to examine the effect of personality on interactive strategies and on the development of interpersonal relationship among college students in Taiwan. Self-report questionnaires were used in this study. Snow-ball and convenient samplings were used to recruit respondents nation-wide in Taiwan. Data for analysis were provided by 206 participants. Data were analyzed by using factor analysis and item analysis to test scale reliability. Pearson correlation and t-test were used to examine the correlations among personality, interactive strategies, and interpersonal relationship, as well as demographic variables. Results indicated that individuals' personality traits could be used to predict their interactive strategies and their interpersonal relationship. Extraversion, openness, conscientiousness were positively correlated with active and interactive strategies, and negatively associated with passive strategies; these three types of personality predicted a better quality of relationship with friends, opposite-sex friends, classmates, teachers and family members. Neuroticism was positively associated with the use of passive strategy, and predicted a low quality of relationship with friends, opposite-sex friends and family members.