Objectives: The aim of this study was to create a standardized operation process for Taiwan government communication with mass media during disease outbreaks. After assessing the government-media communication during the 2003 outbreak of Severe Acute Respiratory Syndrome, we built a model with standard information flows. Methods: Our model was developed from a review of the literature and was then modified on the basis of in-depth individual interviews and focus group interviews from January to April 2004. Results: Our proposed standardized operating process consists of three parts: the unified command center and spokesperson; guidance for three-level interviews; and surveillance and corrections of media coverage. Conclusions: First, when facing serious disease outbreaks, government should employ several spokespersons who speak consistently. Second, media reporters should follow the “three-zone rules” -- media reporting zone, central kitchen zone (media representative permitted only), and media prohibition zone--to cover the outbreak. Third, in case of inaccurate news coverage, the government should contact the appropriate reporters or chief editors to request immediate correction.