This article attempts to examine the relationship between leisure life style and depression degree for College Students. A preliminary scale was first developed and then modified on the basis of an exploratory analysis. Seven dimensions extracted from a set of 30 items based on 399 valid questionnaires from 428 college students of Asia University. The result shows that significant difference of different gender, grade, and parent’s occupation on leisure LS (life style). This study also shows that significant difference between age, pocket money, family's income, On-line hours and depression degree. It’s also significant difference of different leisure LS on depression degree. Generally speaking, the depression degree of College Students is show mid degree, accounts for 42.7%. And showing significant difference of the segments of physical cultivator, socialize person, and on-line group on depression degree.