Indigenous youth are a group of persons who are widely neglected in social policy, social work, and academia. This paper intends to enrich understanding of the difficulties faced by indigenous youth. Qualitative interviews were thus undertaken to survey 11 helpers from Yilan and Hualien counties, in Eastern Taiwan. The findings reveal the direct and indirect impact of the disintegration of tradition, clashes of culture, insufficient resources, and industrial change on indigenous families and young persons, which has had a great influence on the life of indigenous youth and their opportunities for development. An implicit association between geographical location, ethnic difference, cultural integrity, and the above-mentioned structural barriers was also discovered. This might affect the profile of indigenous youth.