Professional Development Schools (PDSs) can potentially affect the quality of teaching and learning of students and teachers. The aim of this research was developing the PDSs Modularized Instruction Learning Model (PDSsMILM) which combines the teaching characteristic of PDSs and Modularized Instruction Learning Model (MILM). This research chosed the Early Childhood Care and Education Department of a Technology University to conduct a study, using "Children's Activity Design and Internship" as the research scope. The research can draw the following conclusions: 1. The teaching experiment verified that the PDSsMILM indeed has feasibility; 2. The experimental teaching results show that the PDSsMILM certainly can enhance students' learning effects; 3. PDSsMILM provides positive effects on learners, improving their interpersonal communication, cooperative competency and coordination.