The issue of the Multiple-College-Entrance-Project has been getting popular for many researchers. Nevertheless, most of such studies were concerned with exploring theoretical arguments rather than giving empirical findings. This study was designed to lessen the above weakness and to discover solid findings based on the data of “Taiwan Higher Education Data System”. The purposes of this study mainly focus on uncovering the cross-group effects of natural and scientific students’ taking the mathematics exam designed for students from the social group. This article will first address the origin of the policy of interdisciplinary exams in the Department Required Test, the number of examinees every year, and the discourses about interdisciplinary exams in recent years. Secondly, this article will compare the grades of the examinees who took the interdisciplinary exams with others who didn’t. Major findings of this study are as follows: First, the design interdisciplinary exams do not influence the equity of exams. Secondly, the performance of the examinees who took interdisciplinary exams are worse than those who didn’t. Last, the level of subjective evaluations within departments of the examinees who took interdisciplinary exams are significantly lower than the others. As a result, even if some natural and scientific students enter the business and financial departments of national universities through interdisciplinary exams, we should not exaggerate the advantages of taking interdisciplinary exams.